Skip to Main Content
Reproductive and Placental Research Unit
YSM Home

INFORMATION FOR

Placenta Research

Articles, chapters, abstracts, and patents regarding Placental Research.

Placental Research

  1. Soto EA, Kliman HJ, Strauss JF III and Paavola L. (1986) Gonadotrophin-induced changes in morphology of human granulosa cells in culture. Biol Reprod 34: 559-569.
  2. Kliman HJ, Nestler JE, Sermasi E, Sanger JM, and Strauss JF III. (1986) Purification, characterization and in vitro differentiation of cytotrophoblasts from human term placentae. Endocrinol. 118: 1567-1582.
  3. Feinman MA, Kliman HJ, Caltabiano S, and Strauss JF III. (1986) 8-Bromo-3'5' AMP stimulates the endocrine activity of human cytotrophoblasts in culture. J Clin End Metab 63: 1211-1217.
  4. Ulloa-Aguirre A., August AM, Golos, TG, Kao L-C, Sukuragi N, Kliman HJ, and Strauss, JF III (1987). 8-Bromo-3'5' adenosine monophosphate regulates expression of chorionic gonadotropin and fibronectin in human cytotrophoblasts. J. Clin. End. Metab., 64: 1002-1009.
  5. Feinman MA, Kliman HJ, and Main EK. (1987) HLA antigen-expression and induction by gamma-interferon in cultured trophoblasts. Am. J. Obstet. Gynecol. 157: 1429-34.
  6. Kliman HJ, Feinman MA and Strauss JF III. (1987) Differentiation of human cytotrophoblasts into syncytiotrophoblasts in culture. Trophoblast Research 2: 407-421.
  7. Roy-Choudhury, S., Sen-Majumdar A., Murthy U, Mishra VS, Kliman HJ, Nestler JE, Strauss JF III, and Das M. (1988). Biosynthesis and turnover of a 34,000 molecular weight protein growth factor in human cytotrophoblasts. Eur J. Biochem. 172: 777-783.
  8. Kao L-C, Caltabiano S, Wu S, Strauss JF III, Kliman HJ. (1988) The human villous cytotrophoblast: Interaction with extracellular matrix proteins, endocrine function, and cytoplasmic differentiation in the absence of syncytium formation. Developmental Biol. 130: 693-702.
  9. Nulsen, JC, Silavin S. L, Kao L-C, Ringler GE, Kliman HJ, and Strauss JF III (1989) Control of the steroidogenic machinery of the human trophoblasts by cyclic AMP. J. Reprod Fert, Suppl., 37: 147-153.
  10. Kliman HJ, Coutifaris C, Babalola GO, Soto EA, Kao L-C, Queenan JT, Feinberg RF, Strauss JF III. (1989) The human trophoblast: Homotypic and heterotypic cell-cell interactions. Prog. Clin. Biol. Res. 294: 425-34.
  11. Feinberg RF, Kao L-C, Haimowitz JE, Queenan JT Jr, Wun T-C Strauss JF III, Kliman HJ. (1989) Plasminogen activator inhibitors types 1 and 2 in human trophoblasts: PAI-1 is a marker of invading trophoblasts. Laboratory Investigation, 61: 20-26.
  12. Babalola, GO, Coutifaris C, Soto EA, Kliman HJ, Shuman H, Strauss JF III. (1990) Aggregation of dispersed human cytotrophoblastic cells: lessons relevant to the morphogenesis of the placenta. Developmental Biology, 137: 100-108.
  13. Kliman HJ, Feinberg RF. (1990) Human trophoblast-extracellular matrix (ECM) interactions in vitro: ECM thickness modulates morphology and proteolytic activity. Proc Natl Acad Sci U S A, 87:3057-3061.
  14. Kliman HJ, Feinberg RF, Haimowitz JE. (1990) Interactions between human term trophoblasts and endometrium in vitro. Colloques INSERM, 199: 3-9.
  15. Kliman HJ, Feinberg RF, Haimowitz JE. (1990) Human trophoblast-endometrial interactions in an in vitro suspension culture system. Placenta, 11:349-367.
  16. Kliman HJ. (1990) Three steps to knowledge. Surgical Pathology, 3:161.
  17. Feinberg RF, Kliman HJ, Lockwood CJ. (1991) Oncofetal fibronectin: A trophoblast "glue" for human implantation? Am J Pathology, 138:537-543.
  18. Kliman HJ, Strauss JF III, Kao L-C, Caltabiano S, Wu S. (1991) Cytoplasmic and biochemical differentiation of the human villous cytotrophoblast in the absence of syncytium formation. Trophoblast Research 5:297-309.
  19. Feinberg RF, Kliman HJ, Cohen AW (1991) Preeclampsia, trisomy 13, and the placental bed. Obstet Gynecol 78:505-8.
  20. Coutifaris C, Babalola GO, Abisogun AO, Kao LC, Chin U, Vadillo OF, Osheroff J, Kliman HJ, Strauss JF3 (1991) In vitro systems for the study of human trophoblast implantation. Ann N Y Acad Sci 622:191-201.
  21. Feinberg RF, Kliman HJ (1992) Fetal fibronectin and preterm labor [letter]. N Engl J Med 326:708; discussion 709.
  22. Kliman HJ. (1993) The placenta revealed. Am J Path 143:332-336.
  23. Feinberg RF, Kliman HJ. (1993) Tropho-uteronectin (TUN): A unique oncofetal fibronectin deposited in the extracellular matrix of the tropho-uterine junction and regulated in vitro by cultured human trophoblasts. Trophoblast Research 7:167-179.
  24. Feinberg RF, Kliman HJ, Wang CL. (1994) Transforming growth factor beta (TGFß) stimulates tropho-uteronectin (TUN) synthesis in vitro: Implications for trophoblast implantation in vivo. J Clin Endocrinology Metabolism 78:1241-48.
  25. Rotmensch S, Liberati M, Juo J-S, Kliman HJ, Gollin Y, Bellati U, Hobbins JC, Copel JA. (1994) Color Doppler flow patterns and flow velocity wave forms of the intraplacental fetal circulation in growth-retarded fetuses. Am J Obstet Gynecol 171:1257-64.
  26. Feinberg RF, Kliman HJ, Bedian V, Monzon-Bordonaba F, Menzin AW, Wang C-L. (1995) Monoclonal antibody X18A4 identifies an oncofetal fibronectin epitope distinct from the FDC-6 binding site. Am J Obstet Gynecol 172:1526-36.
  27. Bahado-Singh RO, Kliman HJ, Feng TY, Hobbins J, Copel JA, Mahoney MJ. (1995) First-trimester endocervical irrigation: feasibility of obtaining trophoblast cells for prenatal diagnosis. Obstet Gynecol 85:461-4.
  28. Kliman HJ Perrotta P, Jones D. (1995) The efficacy of the placental biopsy. Am J Ob Gyn 173:1084-8.
  29. Nachtigall MJ, Kliman HJ, Feinberg RF, Meaddough EL, Arici A. (1996) The effect of leukemia inhibitory factor (LIF) on trophoblast differentiation: A potential role in human implantation. J Clin Endo Met 81:801-6.
  30. Kliman HJ. (2000) Uteroplacental blood flow: The story of decidualization, menstruation and trophoblast invasion. Am J Pathol 157:1759-68.
  31. Kliman HJ, Segel L. (2003) The placenta may predict the baby. J Ther Biol, 225: 143-145 (pdf).
  32. Rejniak KA, Kliman HJ, Fauci LJ. (2004) A computational model of the mechanics of growth of the villous trophoblast bilayer. Bull Math Biol, 66:199-23.
  33. Than NG, Pick E, Bellyei S, Szigeti A, Burger O, Berente Z, Janaky T, Boronkai A, Kliman HJ, Meiri H, Bohn H, Than GN, Sumegi B. (2004) Functional analyses ofplacental protein 13/galectin-13. Eur J Biochem, 271:1065-1078.
  34. Anderson GM, Jacobs-Stannard A, Chawarska K, Volkmar FR, Kliman HJ. Placental Trophoblast Inclusions in Autism Spectrum Disorder, Biological Psychiatry, June 22, 2006
  35. Hecht JL, Kliman HJ, Allred EN, Pflueger SM, Chang CH, Doss BJ, Roberts D, Livasy CA, Bhan I, Zambrano E, Ross DW, Senagore P, Husain AN, Leviton A. (2007) Reference Weights for Placentas Delivered before the 28th Week of Gestation. Placenta, 28:987-90.
  36. Hecht JL, Onderdonk A, Delaney M, Allred EN, Kliman HJ, Zambrano E, Pflueger SM, Livasy CA, Bhan I, Leviton A. (2008) ELGAN Study Investigators. Characterization of chorioamnionitis in 2nd-trimester C-section placentas and correlation with microorganism recovery from subamniotic tissues. Pediatric & Developmental Pathology, 11:15-22.
  37. Hecht JL, Allred EN, Kliman HJ, Zambrano E, Doss BJ, Husain A, Pflueger SM, Chang CH, Livasy CA, Roberts D, Bhan I, Ross DW, Senagore PK, Leviton A, Elgan Study Investigators. (2008) Histological characteristics of singleton placentas delivered before the 28th week of gestation. Pathology, 40:372-6.
  38. Yusuf K,Kliman HJ. (2008) The fetus, not the mother, elicits maternal immunologic rejection: lessons from discordant dizygotic twin placentas. J Perinat Med, 36:291-296.
  39. Funai EF, Labowsky AT, Drewes CE, Kliman HJ. (2009) Timing of Fetal Meconium Absorption by Amnionic Macrophages. Am J Perinatology, 26:93-7.
  40. Lash GE, Ansari T, Bischof P, Burton GJ, Chamley L, Crocker I, Dantzer V, Desoye G, Drewlo S, Fazleabas A, Jansson T, Keating S, Kliman HJ, Lang I, Mayhew T, Meiri H, Miller RK, Nelson DM, Pfarrer C, Roberts C, Sammar M, Sharma S, Shiverick K, Strunk D, Turner MA, Huppertz B 2009 IFPA meeting 2008 workshops report. Placenta 30 Suppl A:S4-14.
  41. Azpurua HJ, Funai EF, Coraluzzi L, Sasson I, Doherty L, Kliman M, Kliman HJ. (2010) Determination of placental weight using two-dimensional sonography and volumetric mathematic modeling, Am J Perinatology, 27:151-155.
  42. Kliman HJ, Sammar M, Gimpel Y, Lynch SK, Milano SK, Pick E, Bejar J, Arad A, Lee JJ, Meiri H, Gonen R. (2012) Placental protein 13 and decidual zones of necrosis: an immunologic diversion that may be linked to preeclampsia. Reproductive Sciences, 19:12-26.
  43. Trivedi S, Joachim M, McElrath T, Kliman HJ, Allred EN, Fichorova RN, Onderdonk A, Heitor F, Chaychi L, Leviton A, Majzoub JA (2012) Fetal-placental inflammation, but not adrenal activation, is associated with extreme preterm delivery. Am J Obstet Gynecol, 206:236e1-e8.
  44. Walker CK, Anderson KW, Milano KM, Ye S, Tancredi DJ, Pessah IN, Hertz-Picciotto I, Kliman HJ. (2013) Trophoblast Inclusions are Significantly Increased in the Placentas of Children in Families at Risk for Autism, Biological Psychiatry, 74:204-211
  45. Arleo EK, Troiano RN, da Silva R, Greenbaum D, Kliman HJ. Utilizing 2-Dimensional Ultrasound to Develop Normative Curves for Estimated Placental Volume (EPV). Am J Perinatology. 2013 Oct 9. [Epub ahead of print]
  46. Kliman HJ. (2014) Comment on “The placenta harbors a unique microbiome.” Sci Transl Med, 6(254):254le4
  47. Stephenson MD, McQueen D, Desjardins MD, Kliman HJ. (2016) Vaginal micronized progesterone started in the luteal phase improves live birth rate in women with recurrent pregnancy loss. Fertility and Sterility, online release
  48. Salvante KG, Milano K, Kliman HJ and Nepomnaschy PA. (2017) Placental 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) expression very early during human pregnancy. Journal of Developmental Origins of Health and Disease, 8(2), pp. 149–154. doi: 10.1017/S2040174416000611
  49. Sonek J, Krantz D, Carmichael J, Downing C, Jessup K, Haidar Z, Ho S, Hallahan T, Kliman HJ, McKenna D. (2018) First trimester screening for early and late preeclampsia using maternal characteristics, biomarkers, and estimated placental volume. American Journal of Obstetrics & Gynecology, 218:126.e1-126.e13; doi: 10.1016/j.ajog.2017.10.024
  50. Isakov KMM, Emerson JW, Campbell KH, Galerneau F, Anders AM, Lee YK, Roberts AE, Kliman HJ. (2018) Estimated placental volume and gestational age. American Journal of Perinatology, 35:748-57, 2018; doi: 10.1055/s-0037-1615285
  51. Kliman HJ, Quaratella SB, Setaro AC, Siegman EC, Subha ZT, Tal R, Milano KM, Steck TL. (2018) Pathway of Maternal Serotonin to the Human Embryo and Fetus. Endocrinology, 159:1609-1629
  52. Yockey LJ, Jurado KA, Arora N, Millet A, Rakib T, Milano KM, Hastings AK, Fikrig E, Kong Y, Horvath TL, Weatherbee S, Kliman HJ, Coyne CB, Iwasaki A. Type I interferons instigate fetal demise after Zika virus infection. Sci Immunol. 2018 Jan 5;3(19)
  53. Mackie DI, Al Mutairi F, Davis RB, Kechele DO, Nielsen NR, Snyder JC, Caron MG, Kliman HJ, Berg JS, Simms J, Poyner DR, Caron KM. hCALCRLmutation causes autosomal recessive nonimmune hydrops fetalis with lymphatic dysplasia. J Exp Med. 2018 Sep 3;215(9):2339-2353
  54. Kliman HJ, Firestein MR, Hofmann KM, Milano KM, Holzer PH, Brink LT, Odendaal HJ, Fifer WP. (2021) Trophoblast inclusions in the human placenta: Identification, characterization, quantification, and interrelations of subtypes. Placenta 103: 172-176, https://doi.org/10.1016/j.placenta.2020.10.014
  55. Katz J, Holzer PH, Kliman HJ, Genetics, not the uterine environment, drive the formation of trophoblast inclusions: Insights from a twin study, Placenta (2021)
  56. A. Lu-Culligan, A.R. Chavan, P. Vijayakumar, L. Irshaid, E.M. Courchaine, K.M. Milano, Z. Tang, S.D. Pope, E. Song, C.B.F. Vogels, W.J. Lu-Culligan, K.H. Campbell, A. Casanovas-Massana, S. Bermejo, J.M. Toothaker, H.J. Lee, F. Liu, W. Schulz, J. Fournier, M.C. Muenker, A.J. Moore, L. Konnikova, K.M. Neugebauer, A. Ring, N.D. Grubaugh, A.I. Ko, R. Morotti, S. Guller, Kliman HJ, A. Iwasaki, S.F. Farhadian, Maternal respiratory SARS-CoV-2 infection in pregnancy is associated with a robust inflammatory response at the maternal-fetal interface, Med 2(5) (2021) 591-610.e10
  57. Firestein MR, Kliman HJ, Sania A, Brink LT, Holzer PH, Hofmann KM, Milano KM, Pini N, Shuffrey LC, Odendaal HJ, Fifer WP. (2022) Trophoblast inclusions and adverse birth outcomes. PLoS ONE 17(3) e0264733. doi.org/10.1371/journal.pone.0264733.pdf
  58. Thompson BB, Holzer PH & Kliman HJ. Placental Pathology Findings in Unexplained Pregnancy Losses. Reprod. Sci. (2023). https://doi.org/10.1007/s43032-023-01344-3